A hematophysiological and organotypic investigation of albino rats' protection against bisphenol A-induced toxicity using chitosan nanoparticles (CS-NPs)

Abstract

The aim of this study was to determine the effect of oral administration of 30% and 40% chitosan nanoparticles on Bisphenol-A (BPA) on liver, spleen and kidney weights, hemoglobin (Hb) concentration, red blood cell count (RBCs), packed cell volume (PCV), platelet count, white blood cell count (WBCs), lymphocyte count, and monocyte count in male albino rats. Bisphenol-A caused a significant decrease (P≤0.05) in the weights of internal organs (liver, spleen and kidneys), hemoglobin concentration, red blood cell count, packed cell volume (PCV), platelet count, and lymphocyte count in male albino rats. When treated with chitosan nanoparticles, there was a significant decrease (p ≤ 0.05) in the number of white blood cells and a significant increase (p ≤ 0.05) in the weight rates of internal organs (liver, spleen, and kidneys), hemoglobin concentration, red blood cell count, packed cell volume (PCV), platelet count, and the percentage of both lymphocytes and monocytes.