Effect of Nano-magnesium oxide (MgO) NPs on some biochemical characteristics in male rats exposed to bisphenol A

Abstract

This study was conducted to determine the effect of oral administration of two concentrations (30, 40)% of Nano magnesium oxide, where the sol-gel method was used to synthesize Nanoparticles of magnesium oxide, where Magnesium nitrate hexahydrate Mg (NO₃)₃⋅6H₂O, deionized water, and Caccinia macranthera plant extract were used as raw materials for magnesium, solvent, and stabilizing agent, respectively. In the relative weight of some internal organs, red blood cell parameters, white blood cell counts, lymphocyte and monocyte ratios, and immunoglobulin values ​​in male albino rats exposed to bisphenol A, Bisphenol-A caused a significant decrease (P ≤ 0.05) in the weight of the liver, spleen, and kidneys, hemoglobin concentration (Hb), red blood cell count (RBCs), packed cell volume (PCV), platelet count, lymphocyte and monocyte ratios, immunoglobulin values, and a significant increase in white blood cell count (WBCs). While a significant increase (P ≤ 0.05) was observed in the weight of the liver, spleen and kidneys, the concentration of hemoglobin Hb, the number of red blood cells RBCs, the packed cell volume PCV, the number of platelets, the percentage of lymphocytes and monocytes, and the values ​​of immunoglobulins, and a significant decrease in the number of white blood cells WBCs when treated with Nano-magnesium oxide.